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Jose Perrez is a 60 year old man who comes to your outer metropolitan Emergency Department at 08.30 am, with what looks like a stroke.

He went to bed at 10 pm last night as usual. At 3 am he got up to go to the toilet and fell.

He reports he was struggling to stand afterwards, but he got himself back to bed. At 7 am he fell again while walking to the kitchen, this time witnessed by his wife. She called an ambulance.

He had a past medical history of sleep apnoea, obesity, hypertension and impaired glucose tolerance.

He takes carvedilol, lercanidipine and atenolol and is not on aspirin or any other anticoagulant. He has no allergies.

He’s usually independent for all activities of daily living and drinks 10 standard drinks per day.

On examination you find:

Alert and oriented

Left-sided visual/sensory neglect

Left-sided homonymous hemianopia

Partial left-sided weakness of left upper and lower limb

Dense sensory loss of left upper and lower limb

Mild-to-moderate dysarthria

Noted significant right lower limb pitting oedema of unclear chronicity – ?DVT

> This is a NIHSS of 14 (explained later in case you’re unfamiliar)

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Can you give a few differential diagnoses for his presentation?


Stroke mimics in rough order of prevalence.

  • Acute ischaemic stroke (AIS)
  • Intracranial haemorrhage
  • Seizure (but no history of loss of consciousness, seizure activity, or postictal state)
  • Sepsis e.g. LRTI (acute illness can unmask pre-existing weakness e.g. from previous AIS)
  • Hypoglycemia
  • Intracranial tumor
  • Hypertensive encephalopathy
  • Intracranial abscess
  • Functional disorder
  • Hyperglycemia
  • Complicated migraines
  • Drug toxicity
  • Multiple sclerosis
  • Wernicke’s encephalopathy
  • Other metabolic abnormalities

REF

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What are your TWO immediate priorities?


> Get immediate initial investigations and imaging – including a CTB and CTA

> If these support a diagnosis of AIS, get him to a stroke centre ASAP

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