MORE TALKS
MAJOR TRIALS
CONCIOUS 2 trial (2011; Lancet) – No benefit for Clazosentan
Allen (1983; NEJM) – Original trial for nimodipine in SAH to prevent vasospasm
Perry (2011; BMJ) – Sensitivity of CT in diagnosis of SAH
Wong (2014; Stroke) – No benefit for statins
MASH 2 Trial (2012; Lancet)- No benefit for IV Magnesium
ISAT Trial ( 2002; Lancet) – improved mortality with coiling vs clipping in aSAH
ONGOING TRIALS
NEW DIRECTIONS
> Single centre before/after study
> IV milrinone was associated with better long-term neurological and radiological outcomes. More studies necessary.
> Prophylactic lumbar cerebrospinal fluid drainage improved clinical outcomes at 6 months. Multi-centre international RCT.